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Rapport de test pinealon 16mg
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Rapport de test pinealon 16mg

Pinealon 16 mg (biorégulateur)

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Pinealon 16mgest un peptide synthétique conçu pour améliorer la fonction cérébrale, améliorer la mémoire et protéger contre les maladies neurodégénératives. Il est connu pour ses propriétés neuroprotectrices et-amélioration cognitive. Pinealon est souvent utilisé pour soutenir la santé du cerveau, améliorer les capacités cognitives et aider à contrer les effets du vieillissement sur le cerveau.

Propriétés clés et utilisations de Pinealon 16 mg:

  1. Cognitive Enhancement:

    • Pinealon est principalement utilisé pour sa capacité à améliorer les fonctions cognitives telles que la mémoire, l'apprentissage et la concentration. Il a été démontré qu'il soutient la production de neurotransmetteurs clés impliqués dans la mémoire et la clarté mentale, ce qui le rend utile pour améliorer les performances mentales.
  2. Neuroprotection:

    • L'un des avantages les plus importants de Pinealon est ses propriétés neuroprotectrices. Il aide à protéger les neurones contre le stress oxydatif, qui est une cause principale de maladies neurodégénératives comme Alzheimer et Parkinson. Ce peptide soutient la santé du cerveau à long terme et peut aider à réduire le risque de déclin cognitif.
  3. Anti-Aging Effects:

    • Pinealon a été étudié pour son potentiel pour ralentir le processus de vieillissement dans le cerveau. En favorisant la réparation et la régénération cellulaire, il aide à atténuer les effets cognitifs du vieillissement, à maintenir la netteté mentale et à prévenir la perte de mémoire liée à l'âge.
  4. Mood Regulation:

    • En plus de ses avantages cognitifs, Pinealon s'est également avéré soutenir la réglementation de l'humeur. Cela peut aider à réduire les symptômes d'anxiété et de dépression en modulant les neurotransmetteurs tels que la sérotonine et la dopamine, qui sont essentiels au bien-être émotionnel.
  5. Recovery from Brain Injury:

    • Pinealon est parfois utilisé dans le processus de récupération après des lésions cérébrales traumatiques (TBI). Il aide à accélérer la guérison des tissus cérébraux et à améliorer la fonction cérébrale globale pendant la phase de récupération.
  6. Enhances Synaptic Plasticity:

    • Pinealon fonctionne en améliorant la plasticité synaptique, qui est essentielle à la capacité du cerveau à s'adapter à un nouvel apprentissage et à de nouveaux expériences. Cela la rend précieuse pour les personnes qui cherchent à augmenter leur capacité de mémoire et leur adaptabilité cérébrale.

Administration et dosage:

  • Administration: Pinealon 16 mg est généralement administré par injection sous-cutanée. Cette méthode garantit que le peptide est absorbé efficacement dans la circulation sanguine pour une action ciblée sur les cellules cérébrales.

  • Dosage: La dose recommandée de pinealon est généralement de 16 mg par injection, la fréquence et la durée d'utilisation variant en fonction des objectifs individuels et des besoins de santé. Il est important de suivre les conseils médicaux pour une utilisation appropriée, en particulier pour ceux qui l'utilisent pour gérer le déclin cognitif ou les conditions neurodégénératives.

Considérations et avertissements:

  • Effets secondaires: Pinealon est généralement bien toléré, mais certaines personnes peuvent éprouver des effets secondaires légers tels que les maux de tête, les étourdissements ou un léger inconfort au site d'injection. Ceux-ci sont généralement temporaires et se calment car le corps s'adapte au peptide.

  • Supervision médicale: En raison des effets sur la fonction cérébrale, le pinealon doit être utilisé sous la supervision d'un fournisseur de soins de santé, en particulier pour les personnes souffrant de conditions neurologiques préexistantes ou celles qui subissent des traitements de santé cognitifs.

  • Statut réglementaire: Bien que Pinealon se soit révélé prometteur dans diverses études, il peut ne pas être largement approuvé pour une utilisation clinique dans toutes les régions. Il est souvent commercialisé en tant que peptide de recherche, et son utilisation doit être conforme aux réglementations locales.

Résumé:

Pinealon 16 mg offre une approche ciblée pour améliorer la fonction cognitive, protéger contre les maladies neurodégénératives et soutenir la santé globale du cerveau. Ses propriétés neuroprotectrices et cognitives en rendent la valeur à la fois pour les individus en bonne santé et ceux qui traitent du déclin cognitif lié à l'âge. Cependant, en raison de ses puissants effets biologiques, il doit être utilisé avec une surveillance médicale.

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Pinealon est un peptide synthétique seulement trois acides aminés de longueur. Il a été démontré qu'il modifie le comportement et protège un certain nombre de types de cellules contre les effets de l'hypoxie. Il a subi des recherches approfondies pour sa capacité à altérer le rythme circadien, à améliorer la mémoire et à améliorer l'apprentissage. Il a été démontré qu'il compense les effets du vieillissement, en particulier dans le système nerveux central, et peut être utile dans le traitement des troubles cognitifs comme la maladie d'Alzheimer.

Utilisation du produit:Ce produit est conçu uniquement comme un produit chimique de recherche.Cette désignation permet l'utilisation de produits chimiques de recherche strictement pour les tests in vitro et l'expérimentation de laboratoire uniquement. Toutes les informations sur les produits disponibles sur ce site Web sont à des fins éducatives uniquement. L'introduction corporelle de toute nature dans l'homme ou les animaux est strictement interdite par la loi. Ce produit ne doit être géré que par des professionnels agréés et qualifiés. Ce produit n'est pas une drogue, de la nourriture ou un cosmétique et peut ne pas être mal étendu, mal utilisé ou erroné comme drogue, aliment ou cosmétique.

Qu'est-ce que Pinealon?

Pinealon est un peptide court composé de seulement trois acides aminés. Il s'agit d'une poignée de peptides synthétiques appelés biorégulateurs peptidiques pour leur capacité à interagir directement avec l'ADN pour modifier les niveaux d'expression des gènes. Pinealon a été lié à la modification du comportement et est censé aider à protéger un certain nombre de types de cellules, y compris les neurones, contre les effets de l'hypoxie. Par effet direct sur la glande pinéale, Pinealon peut réduire les problèmes de métabolisme des médicaments, de troubles du rythme circadien, de mémoire, d'apprentissage, etc.

Structure de pinealon

Structure de pinealonSource:Se publier

Séquence:Glu-asp-arg
Formule moléculaire:C15H26N6O8
Poids moléculaire:418,407 g / mol
PubChem CID: 18220191
Synonymes:Glutamylaspartylarginine, peptide T-33

Pinealon interagit directement avec l'ADN

Contrairement à la plupart des peptides, Pinealon ne semble pas se lier à la surface cellulaire ou aux récepteurs cytoplasmiques. Cela a conduit les scientifiques à se demander comment le peptide court peut avoir un effet. Dans le passé, il a été suggéré que Pinealon peut être suffisamment petit pour traverser les bicouches lipidiques (par exemple la membrane cellulaire, la membrane nucléaire) et peut donc être capable d'interagir directement avec l'ADN. Les tests dans les cultures cellulaires (cellules HeLa) indiquent que le pinealon pénètre directement la membrane cellulaire ainsi que la membrane nucléaire pour interagir avec l'ADN[1]. This makes pinealon a regulator of gene expression and explains the peptide’s myriad effects that cannot be explained by receptor interactions.

Pinealon Research

Pinealon Research and Aging

Pinealon may have anti-aging effects in the central nervous system. Research from Russia indicates that pinealon and a similar peptide, vesugen, are anabolic in the brain and can actually slow the rate of aging when calculated using biological age indicators[2].

Pinealon is active in cells outside of the central nervous system as well. Research shows that the peptide also has effects on muscle cells where it alters the expression of irisin[3]. Irisin is important to protecting muscle cells during exercise, promotes fat burning, and is thought to induce telomere elongation as well. By increasing the lifespan of irisin, pinealon boosts telomere protection and helps to fight off the effects of aging and oxidative stress. In fact, plasma irisin levels are directly linked to telomere length in healthy adults and levels of the enzyme have been directly linked to calorie restriction, one of the few activities known beyond doubt to prolong life and improve overall fitness[4]. Interestingly, there is evidence that irisin is active outside of muscle cells and that pinealon may therefore have anti-aging effects that are broadly distributed throughout the body, including the brain.

Pinealon Research and Neuron Protection

Research in prenatal rats indicates that pinealon protects neurons against oxidative stress and thus protects cognitive function and motor coordination[5]. The study showed marked decreases in both reactive oxygen species accumulation as well as number of necrotic cells in the brain in these rats. In other words, pinealon protects neurons from dying.

The findings of the prental rat study discussed above have been confirmed in separate studies and extended in others. Confirmation that pinealon protects against reactive oxygen species and reduces necrotic cell death also came with the understanding that the peptide modifies the cell cycle as part of its protection against cell death[6]. This was one of the first indications that pinealon was almost certainly interacting at the level of DNA. Interestingly, pinealon modulates the cell cycle by activating proliferation pathways. Under normal circumstances, this would lead to an increase in cell number, but under the setting of oxidative stress, this effect simply offsets some of the damaging effects of reactive oxygen species.

Measure of reactive oxygen species in controls, those exposed to ouabain, and animals exposed to both ouabain and pinealon at various doses.Measure of reactive oxygen species in controls, those exposed to ouabain, and animals exposed to both ouabain and pinealon at various doses.
Source: Semantic Scholar

Research in adult rats deprived of oxygen has also shown that pinealon increases the resistance of neurons to hypoxic stress. It appears to do this by stimulating innate anti-oxidative enzyme systems and limiting the excitotoxic effects of N-methyl-D-aspartate[7]. N-methyl-D-aspartate (NMDA) is an amino acid derivative that can kill nerve cells by over-exciting them. NMDA has been shown to become overactive during withdrawal from alcohol and is at least partly responsible for the “shakes” or delirium tremors that affects chronic alcoholics during withdrawal. NMDA has been linked to nerve death in traumatic brain injury and ischemic stroke.

Irisin, which has been discussed in the context of muscle cell protection, has recently been found in the brain where it plays important roles in neural differentiation, proliferation, and energy expenditure. Irisin levels in the central nervous system has been found to stimulate genes in the hippocampus that are important to memory, learning, the overall neuron health[8]. Research in rats suggests that exercise directly boosts levels of irisin in the brain, which may finally provide the link between physical activity and cognition. Scientists have speculated that irisin is the messenger that mediates crosstalk between skeletal muscle and the central nervous system during exercise. Pinealon boosts levels of irisin by altering expression of the gene that codes for the enzyme. This leads to increased levels of irisin through prolonged lifespan of the enzyme.

Pinealon research and Depression

Research in cultures of brain cortex cells indicate that pinealon can boost expression of 5-tryptophan hydroxylase via epigenetic changes. 5-tryptophan hydroxylase is critical to the production and secretion of serotonin, a peptide known to have neuroprotective and geroprotective features[9]. It is also the signaling molecule most often targeted by anti-depressive drugs called selective-serotonin reuptake inhibitors (SSRIs). SSRIs have a number of side effects, however, and the ability to boost serotonin production organically could offer a means of fighting depression that is more physiologic and thus reduce side effects.

Pinealon Protects Cells from Caspase-3 and Cell Death

The initial understanding that pinealon could affect the cell cycle came from research into the effects of the peptide in rat models of ischemic stroke. These studies revealed that pinealon affects cytokine signaling that normally leads to an increase in levels of the caspase-3 enzyme[10]. Caspase-3 is directly responsible for initiating apoptosis, or the controlled death of a cell via genetic instruction. By modulating caspase-3, pinealon shuts down at least one pathway to cell death and thus reduces the effects of oxygen deprivation during stroke.

Caspase-3 is not only active in neurologic tissue though, it is almost universal. Research using models of heart attack indicates that pinealon may reduce caspase-3 levels following myocardial infarction[11]. The short peptide may have application both in treating heart attack and in preventing the long-term remodeling that causes so much dysfunction following a myocardial infarction.

The benefit of pinealon in suppressing caspase-3 expression has been demonstrated in skin cells. By reducing apoptosis in the skin, pinealon promotes cell proliferation in both young and old animals alike. This leads to an increase in the regenerative process and has been shown to offset age-related pathology in the skin[12]. Pinealon may eventually form part of a multi-faceted approach to wound healing and could have application in everything from sun protection to serious burn treatment.

Pinealon Research and Sleep Regulation

It should come as no surprise, given its names, that pinealon affects that sleep-wake cycle as well as sleep behavior. Research indicates, that pinealon may help to regulate the dysfunction caused by shift-work and other activities (e.g. long-distance travel) that interfere with normal sleep patterns. The peptide actually appears to reset the pineal gland to baseline in the setting of circadian rhythm disruption, improving sleep, depression, mood, blood pressure, and more as a result[13].

The ability to regulate sleep actually corresponds strongly with rates of aging. Disturbed sleep is a recipe for disaster in the body and affects cognition, cardiac health, wound healing, mood, and more. Pinealon may therefore help to reduce the impact of sleep disturbance and thus offset the effects that it has on aging. This could be beneficial not only to those forced into disorder sleep due to their jobs, but to individuals suffering from organic disease that impacts sleep-wake cycles.

Pinealon exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Pinealon for sale at

Peptide Gurus is limited to educational and scientific research only, not for human consumption. Only buy Pinealon if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Vladimir Khavinson is a Professor, President of the European region of the International Association of Gerontology and Geriatrics; Member of the Russian and Ukrainian Academies of Medical Sciences; Main gerontologist of the Health Committee of the Government of Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice-president of Gerontological Society of the Russian Academy of Sciences; Head of the Chair of Gerontology and Geriatrics of the North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired. Vladimir Khavinson is known for the discovery, experimental and clinical studies of new classes of peptide bioregulators as well as for the development of bioregulating peptide therapy. He is engaged in studying of the role of peptides in regulation of the mechanisms of ageing. His main field of actions is design, pre-clinical and clinical studies of new peptide geroprotectors. A 40-year-long investigation resulted in a multitude of methods of application of peptide bioregulators to slow down the process of aging and increase human life span. Six peptide-based pharmaceuticals and 64 peptide food supplements have been introduced into clinical practice by V. Khavinson. He is an author of 196 patents (Russian and international) as well as of 775 scientific publications. His major achievements are presented in two books: “Peptides and Ageing” (NEL, 2002) and “Gerontological aspects of genome peptide regulation” (Karger AG, 2005). Vladimir Khavinson introduced scientific specialty “Gerontology and Geriatrics” in the Russian Federation on the governmental level. Academic Council headed by V. Khavinson has oversighted over 200 Ph.D. and Doctorate theses from many different countries.

Prof. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Pinealon. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between

Peptide Gurus and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Prof. Vladimir Khavinson is listed in [1] [3] [5] [6] and [9] under the referenced citations.

 

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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