Retatrutide, known by its CAS number 2381089-83-2, is a peptide compound gaining significant attention in scientific research—especially in studies related to metabolism and obesity. Its unique mechanism lies in being a triple agonist of GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), and GCGR (Glucagon Receptor), which means it targets three key pathways involved in regulating blood sugar and fat metabolism. For researchers, this makes it a valuable tool to explore how multi-target peptides influence physiological processes linked to conditions like type 2 diabetes and obesity.

Chemically, Retatrutide has a molecular formula of C221H342N46O68 and a molecular weight of approximately 4731.33 g/mol. It typically appears as a white lyophilized (freeze-dried) powder, a form that preserves its stability and biological activity—critical for reliable experiment results. At PeptideGurus, our Retatrutide powder meets the highest standards for research use: we guarantee a purity of 99% or higher, verified through third-party testing. This high purity ensures that researchers can minimize interference from impurities, leading to more accurate and reproducible data in their studies.

As a trusted supplier of American-manufactured research peptides, PeptideGurus designs its Retatrutide powder to address the practical needs of labs. Here are the core advantages that set our product apart:

First, uncompromising quality assurance. We source our Retatrutide exclusively from manufacturers certified by WHO/GMP and ISO 9001:2008—standards that align with global best practices for peptide production. Every batch undergoes rigorous testing to confirm purity (99%+), impurity levels (with single impurities below 1%), and stability, so you can trust that the product you receive meets consistent, high-quality benchmarks.

Second, flexible specifications for all experiment scales. Whether you’re conducting small-scale preliminary tests or larger mid-stage studies, we offer Retatrutide in a range of formats: from 50mg vials for initial trials to gram-scale powder for extended projects. We also provide encapsulated options (e.g., 12.5mg per capsule) for experiments that require precise, pre-measured doses—saving you time on manual weighing and reducing the risk of measurement errors.

Third, reliable storage and global delivery. Retatrutide is sensitive to heat, light, and moisture, so we package it in airtight, light-resistant containers and recommend storage at 2–8°C (36–46°F) to maintain its activity. To ensure fast, safe delivery, we stock Retatrutide in warehouses across the USA, Europe, Canada, the UK, and Mexico. This means most researchers receive their orders within 2–5 business days, with real-time shipping tracking and temperature-controlled packaging (when needed) to protect the product during transit.

Fourth, transparency for compliance. Every Retatrutide order from PeptideGurus includes detailed documentation: a certificate of analysis (CoA) confirming purity and testing results, and clear labeling stating “For Laboratory Research and Development Only”—a critical detail to align with regulatory guidelines (more on this below).

The U.S. Food and Drug Administration (FDA) has issued updated guidelines for research-use peptides (RUPs) to ensure safety, quality, and ethical use in scientific studies. As a researcher, understanding these guidelines is essential to avoid compliance risks—and PeptideGurus’ Retatrutide powder is designed to meet these requirements:

GMP-compliant production: The FDA mandates that RUPs must be manufactured in facilities following Good Manufacturing Practices (GMP) to ensure consistency and minimize contamination risks. Our Retatrutide is produced by GMP-certified partners, and we conduct regular audits to verify adherence to these standards.

Clear labeling and intended use: The FDA requires RUPs to be clearly labeled with their intended purpose (“Not for Human Use,” “For Research Only”) and to exclude any claims of clinical benefit (e.g., “treats obesity”). PeptideGurus’ Retatrutide packaging and product descriptions strictly follow this rule, so you can avoid misclassification or regulatory scrutiny.

Quality control documentation: The FDA recommends that researchers request a CoA for any RUP, as it provides proof of purity, impurity levels, and stability. PeptideGurus automatically includes a CoA with every Retatrutide order, so you have a record of quality for your lab’s compliance files.

Safety data sheets (SDS): For handling and disposal, the FDA encourages labs to use SDS documents to identify hazards (e.g., skin irritation risks) and safe practices. We provide a comprehensive SDS for Retatrutide, outlining proper PPE (gloves, goggles), spill cleanup procedures, and waste disposal guidelines.

Retatrutide’s triple-target mechanism makes it versatile for a range of scientific studies. Here are the most common ways researchers use our Retatrutide powder—explained in simple terms:

Metabolic disorder research: Many labs use Retatrutide to study obesity and type 2 diabetes in cell or animal models. For example, researchers might test how Retatrutide affects fat oxidation (the body’s ability to break down fat) or insulin sensitivity (how well cells respond to insulin) in mice. Its triple-target action allows scientists to compare its effects to single-target peptides (e.g., GLP-1-only agonists) and explore if multi-target approaches are more effective for treating metabolic diseases.

Pharmacology studies: To understand how Retatrutide works at the molecular level, researchers use it in receptor-binding experiments. These tests measure how strongly Retatrutide attaches to GLP-1, GIP, and GCGR receptors—data that helps determine the peptide’s potency and potential for future drug development.

Dose-response experiments: Before scaling up studies, researchers need to identify the optimal Retatrutide dose for their model (e.g., cell cultures, zebrafish, or rats). Our powder’s high purity ensures that dose-response curves are accurate—no impurities skew results by interacting with cells or receptors.

Stability and formulation research: Some labs focus on improving peptide delivery (e.g., developing longer-acting formulations). Retatrutide powder is ideal for these studies because its lyophilized form is stable, and researchers can test how different solvents (e.g., DMSO, water) or additives affect its activity.

To get the most out of your Retatrutide powder—and ensure safety—follow these practical tips:

Store correctly from day one: Upon receiving your order, immediately place Retatrutide in a refrigerator (2–8°C). Do not freeze it unless specified in your experiment protocol (freezing can cause peptide aggregation, reducing activity). When opening the container, let it reach room temperature first to prevent moisture from condensing on the powder (moisture leads to degradation).

Handle with care: Retatrutide is a research chemical, not a drug. Always wear gloves, a lab coat, and goggles when weighing or dissolving the powder. Avoid inhaling the powder or letting it touch your skin—if contact occurs, rinse with water immediately.

Dissolve properly: Use a high-purity solvent (e.g., sterile water, DMSO) that matches your experiment’s needs. For example, if testing on cells, use a solvent that’s non-toxic to your cell line. Follow the solubility guidelines: Retatrutide dissolves at 50 mg/mL in DMSO (with sonication to aid mixing) and 20 mg/mL in water (adjust pH to 9 with ammonia water if needed).

Use fresh solutions: Once dissolved, Retatrutide solutions are less stable. Prepare only what you need for a single experiment, and discard any unused solution after 24 hours (even if stored in the fridge).

No. Our Retatrutide is explicitly labeled “For Laboratory Research and Development Only” and does not meet the FDA’s standards for human use (e.g., it lacks clinical-grade purity testing and sterility validation). Using it in humans is unethical, illegal, and poses serious health risks.

Room temperature (especially above 25°C) and light will cause Retatrutide to degrade. Degraded peptide may lose activity, leading to unreliable experiment results. If your Retatrutide was left at room temperature for more than 4 hours, we recommend discarding it and ordering a new batch—this is safer than risking flawed data.

Yes. Every order includes a certificate of analysis (CoA) showing purity, impurity levels, and testing methods—all aligned with FDA recommendations for RUPs. We also provide documentation of our manufacturers’ WHO/GMP and ISO 9001:2008 certifications upon request, so you can confirm compliance.