• Selank peptide in pain management exploration
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Selank 10mg

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Selankis een korte, synthetische analoog van Tuftsin. Het heeft diepgaande anti-angstige eigenschappen. Selank stimuleert ook geheugen en leren en is aangetoond dat het gunstige effecten heeft op pijnperceptie.
Productgebruik:Dit product is alleen bedoeld als een onderzoeks chemisch.Deze aanduiding maakt het gebruik van onderzoekschemicals strikt mogelijk voor alleen in vitro testen en laboratoriumexperimentatie. Alle productinformatie die op deze website beschikbaar is, is alleen voor educatieve doeleinden. Lichamelijke introductie van welke aard dan ook in mensen of dieren is ten strengste wettelijk verboden. Dit product mag alleen worden afgehandeld door erkende, gekwalificeerde professionals. Dit product is geen medicijn, voedsel of cosmetisch en is mogelijk niet verkeerd, misbruikt of misbruikt als medicijn, voedsel of cosmetisch.

Selank Overzicht

Selank, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life. Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.

Selank -structuur

Selank Structure Reeks: Thr-lys-Pro-Pro-Pro-Gly-ProMoleculaire formule: C33H57N11O9 Molecuulgewicht: 751.887 g/molPubchem cid: 11765600CAS -nummer: 129954-34-3Synoniemen: Selanc Source:Pubch

Selank onderzoek

Selank angsteffecten op basis van genen gerelateerd aan GABA Neurotransmitter

Accredit voor Dr. Anastasiya Volkova vanHet Institute of Molecular Genetics in Rusland, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia. Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA[1]. Deze wijziging van de receptoraffiniteit verklaart waarschijnlijk waarom Selank synergetisch is met benzodiazepines en andere GABA -receptoragonisten.Veranderingen in genexpressie als functie van tijd bij ratten behandeld met Selank.Changes in gene expression as a function of time in rats treated with Selank. Source:PubMedOnderzoek bij ratten toont aan dat Selank en Benzodiazepines, wanneer alleen gebruikt, vergelijkbare effecten hebben op angst, met name gegeneraliseerde angststoornis. Selank kan een licht voordeel hebben ten opzichte van benzodiazepines bij het proberen om verhoogde niveaus van angst te verminderen, maar een combinatie van de twee behandelingen lijkt de beste te zijn bij de behandeling van onvoorspelbare chronische milde stress[2]. The effects that Selank has on GABA receptors may be modulated, to some degree, by the peptide’s effect on enkephalin degradation. Testing indicates that people with anxiety and phobic disorders demonstrate increased enkephalinase activity in the blood during generalized anxiety and, as a result, the enkephalins they produce have shorter half-lives[3]. Door afbraak van enkefalines te voorkomen door remming van enhefalinaseremming, kan Selank deze enzymatische route resetten en de natuurlijke anxiolytische peptiden van het lichaam helpen beschermen. Onderzoek bij muizen die vatbaar zijn voor angst, ondersteunt de hypothese dat ten minste een deel van de impact die Selank heeft, het gevolg is van het voorkomen van enhefaline -afbraak[4].

Selank en het immuunsysteem in angst

Onderzoek bij patiënten met depressie geeft aan dat Selank het genen kan onderdrukken dat verantwoordelijk is voor de productie van de inflammatoire cytokine IL-6. Interessant is dat dit effect alleen wordt gezien bij patiënten met een depressie en lijkt niet te plaatsvinden bij gezonde personen[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression. When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins. Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops. Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation[8].

Selank onderzoek met geheugen en leren

There has long been an association between anxiety and learning/memory. The correlation is a negative one, with increased anxiety leading to decreased ability to recall memories or store new information. Traditional anxiety treatments can reduce this effect, as can Selank, but Selank appears to do more than simply reduce the impact of anxiety on cognitive function. There is good reason to believe that Selank actually boosts cognition directly. Research in rats trains with food rewards and injected with either saline or Selank has shown that Selank boosts memory trace stability and thus enhances the memory storage process[9]. It is important to note that this benefit was seen regardless of the anxiety levels of the rats, indicating that the peptide has effects beyond its ability to simply reduce stress-related impairment of memory. It appears that Selank may alter memory by affecting the expression of a number of genes in the hippocampus. Research in rats shows changes in mRNA levels of 36 different genes after intranasal administration of Selank. Most of the genes encode proteins associated with the plasma membrane and may therefore modulate ion-dependent processes in learning and memory[10]. Though much research needs to be done to understand the mechanism by which Selank works to improve memory and learning, this research offers a tantalizing early clue to suggest that it alters the way neurons function in such a way that both forming and accessing memories is easier. Research even suggests that Selank can help to rescue memory and learning following damage to the brain. Rats treated with a neurotoxin and then Selank showed restored cognitive processes in at least one study. This effect appears to be related to an artificial inhibition of the catecholamine system in the brain by Selank[11]. Er is enige hoop dat Selank zal helpen om licht te werpen op hoe de cognitieve functie kan worden hersteld of op zijn minst verbeterd na traumatisch hersenletsel, met name het soort letsel dat zich voordoet tijdens het geboorteproces.

Selank onderzoek en pijn

Selank kan handelen om de afbraak van natuurlijke enkefalines te verminderen door de enzymen te remmen, gevonden in menselijk bloed, die ze afbreken[12]. Enkephalins are natural peptides that bind to opioid receptors and help to blunt the severity of pain. They also function in the human stress response and are found in high levels in the brain and adrenal glands. By reducing levels of enkephalins in the brain, Selank may help to blunt the normal stress response and the effects that it has on memory, learning, and concentration. Selank exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Selank for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Selank if you are a licensed researcher.

Artikelauteur

De bovenstaande literatuur werd onderzocht, bewerkt en georganiseerd door Dr. Logan, M.D. Dr. Logan behaalde een doctoraat vanCase Western Reserve University School of Medicineen een B.S. in moleculaire biologie.

Wetenschappelijke tijdschrift Auteur

Dr. Petr Slominsky‘s 169 research works with 803 citations. 12 of those papers pertain to the examination of Selank’s diverse, multifaceted effects e.g. anxiety reduction, changes in the transcription profile of the hippocampus, and changes in expression of the genes for chemokines, cytokines, and their receptors. Dr. Slominsky is particularly interested in the epigenetic effects of Selank and other disease-state pathologies. Dr. Petr Slominskyis being referenced as one of the leading scientists involved in the research and development of Selank. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Sciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide.Dr. Petr Slominsky is listed in [7] under the referenced citations.

Vermeld citaten

    A. Volkova et al., “Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission,” Front. Pharmacol., vol. 7, Feb. 2016. [PubMed] A. Kasian et al., “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats,” Behavioural Neurology, 2017. [Online]. Available:https://www.hindawi.com/journals/bn/2017/5091027/. A. A. Zozulya et al., “The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity,” Bull. Exp. Biol. Med., vol. 131, no. 4, pp. 315–317, Apr. 2001. [PubMed] O. Y. Sokolov, V. K. Meshavkin, N. V. Kost, and A. A. Zozulya, “Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions,” Bull. Exp. Biol. Med. [PubMed] O. N. Uchakina et al., “[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders],” Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, vol. 108, no. 5, pp. 71–75, 2008. [PubMed] A. A. Zozulia et al., “[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia],” Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, vol. 108, no. 4, pp. 38–48, 2008. [PubMed] T. Kolomin, M. Shadrina, L. Andreeva, P. Slominsky, S. Limborska, and N. Myasoedov, “Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank,” Regul. Pept., vol. 170, no. 1–3, pp. 18–23, Oct. 2011. [PubMed] T. I. Agapova et al., “[Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex],” Mol. Genet. Mikrobiol. Virusol., no. 3, pp. 28–32, 2008. [PubMed] T. P. Semenova, I. I. Kozlovskiĭ, N. M. Zakharova, and M. M. Kozlovskaia, “[Experimental optimization of learning and memory processes by selank],” Eksp. Klin. Farmakol., vol. 73, no. 8, pp. 2–5, Aug. 2010. [PubMed] T. A. Kolomin et al., “[c],” Zh. Vyssh. Nerv. Deiat. Im. I. P. Pavlova, vol. 63, no. 3, pp. 365–374, Jun. 2013. T. P. Semenova, M. M. Kozlovskaya, N. M. Zakharova, I. I. Kozlovskii, and A. V. Zuikov, “Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny,” Bull. Exp. Biol. Med., vol. 144, no. [PubMed] N. V. Kost et al., “[Semax and selank inhibit the enkephalin-degrading enzymes from human serum]],” Bioorg. Khim., vol. 27, no. 3, pp. 180–183, Jun. 2001. [Springer]
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