Selank, which was developed in Russia, is a short peptide with nootropic and anxiolytic properties. It is a synthetic analogue of naturally occurring Tuftsin, an immunomodulatory peptide that modulates IL-6, T helper cells, monoamine neurotransmitters, and brain-derived neurotropic factor (BDNF). In fact, Selank and Tuftsin are essentially the same except that Selank has an additional four amino acids in its chain that help to improve metabolic stability and half-life. Selank has been tested in clinical trials as a potential treatment for generalized anxiety disorder.

Sequence：thr-lys-pro-arg-pro-gly-pro Molecular Formula：c₃₃h₅₇n₁₁o₉ Molecular Weight：751.887 g/mol PubChem CID：11765600 CAS Number：129954-34-3 Synonyms: Selanc Source: PubChem

GABA神経伝達物質に関連する遺伝子に基づくセランク不安効果

According to Dr. Anastasiya Volkova of ロシアの分子遺伝学研究所, “numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of anxiety. The clinical effects of Selank are similar to those of the classical antianxiety medications such as benzodiazepine, which are allosteric modulators of GABAA receptors and increase the inhibitory action of GABA.” Selank’s effects include reducing anxiety, improving mood, lower stress levels, and positively influencing memory and learning. Like benzodiazepines, low doses of Selank have a sedating effect. Unlike benzodiazepines, Selank does not appear to be habit-forming and does not lead to symptoms of withdrawal or amnesia. Research in rats shows that of the 84 genes known to be connected to GABA signaling in some way, seven are heavily modulated by Selank and 45 show some change in expression when the peptide is administered. Overall, 52 genes related to GABA signaling are affected by Selank to some degree. These results indicate that Selank can directly influence the expression of genes in nerve cells and that it likely produces effects by changing the affinity of the GABA receptor for GABA^[1]。受容体の親和性のこの変化は、Selankがベンゾジアゼピンおよび他のGABA受容体アゴニストと相乗的である理由を説明する可能性が高い。 Changes in gene expression as a function of time in rats treated with Selank. Source: PubMed ラットの研究によると、SelankとBenzodiazepinesは単独で使用すると、不安、特に全身性不安障害に同様の影響を与えることが示されています。 Selankは、不安のレベルの上昇を試みるときにベンゾジアゼピンよりもわずかな利点を保持する可能性がありますが、2つの治療の組み合わせは、予測不可能な慢性ストレスの治療に最適であるように思われます^[2]. The effects that Selank has on GABA receptors may be modulated, to some degree, by the peptide’s effect on enkephalin degradation. Testing indicates that people with anxiety and phobic disorders demonstrate increased enkephalinase activity in the blood during generalized anxiety and, as a result, the enkephalins they produce have shorter half-lives^[3]。エンケファリナーゼ阻害を介したエンケファリンの分解を防ぐことにより、セランクはこの酵素経路をリセットし、身体の自然な不安分解ペプチドを保護するのに役立つ可能性があります。不安に陥りやすいマウスの研究は、Selankが持つ影響の少なくとも一部がEnkephalinの分解を妨げた結果であるという仮説を支持しています^[4].

Selankと不安の免疫系

うつ病患者の研究は、Selankが炎症性サイトカインIL-6の産生の原因となる遺伝子を抑制できることを示しています。興味深いことに、この効果はうつ病の患者にのみ見られ、健康な人では起こっていないようです^[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression. When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain^[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins. Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system^[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops. Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation^[8].

記憶と学習を備えたSelank研究

There has long been an association between anxiety and learning/memory. The correlation is a negative one, with increased anxiety leading to decreased ability to recall memories or store new information. Traditional anxiety treatments can reduce this effect, as can Selank, but Selank appears to do more than simply reduce the impact of anxiety on cognitive function. There is good reason to believe that Selank actually boosts cognition directly. Research in rats trains with food rewards and injected with either saline or Selank has shown that Selank boosts memory trace stability and thus enhances the memory storage process^[9]. It is important to note that this benefit was seen regardless of the anxiety levels of the rats, indicating that the peptide has effects beyond its ability to simply reduce stress-related impairment of memory. It appears that Selank may alter memory by affecting the expression of a number of genes in the hippocampus. Research in rats shows changes in mRNA levels of 36 different genes after intranasal administration of Selank. Most of the genes encode proteins associated with the plasma membrane and may therefore modulate ion-dependent processes in learning and memory^[10]. Though much research needs to be done to understand the mechanism by which Selank works to improve memory and learning, this research offers a tantalizing early clue to suggest that it alters the way neurons function in such a way that both forming and accessing memories is easier. Research even suggests that Selank can help to rescue memory and learning following damage to the brain. Rats treated with a neurotoxin and then Selank showed restored cognitive processes in at least one study. This effect appears to be related to an artificial inhibition of the catecholamine system in the brain by Selank^[11]。 Selankが、外傷性脳損傷、特に出生プロセス中に発生する種類の外傷性脳損傷の後に、認知機能をどのように回復できるか、少なくとも改善できるかについての光を当てるのに役立つという希望があります。

Selankの研究と痛み

Selankは、それらを分解する酵素を阻害することにより、天然のエンケファリンの分解を減らすように作用する可能性があります。^[12]. Enkephalins are natural peptides that bind to opioid receptors and help to blunt the severity of pain. They also function in the human stress response and are found in high levels in the brain and adrenal glands. By reducing levels of enkephalins in the brain, Selank may help to blunt the normal stress response and the effects that it has on memory, learning, and concentration. Selank exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Selank for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Selank if you are a licensed researcher.

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Dr. Petr Slominsky‘s 169 research works with 803 citations. 12 of those papers pertain to the examination of Selank’s diverse, multifaceted effects e.g. anxiety reduction, changes in the transcription profile of the hippocampus, and changes in expression of the genes for chemokines, cytokines, and their receptors. Dr. Slominsky is particularly interested in the epigenetic effects of Selank and other disease-state pathologies. Dr. Petr Slominsky is being referenced as one of the leading scientists involved in the research and development of Selank. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Sciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Dr. Petr Slominsky is listed in [7] under the referenced citations.

1. A. Volkova et al。、「Selank投与は、GABA作動性神経伝達に関与するいくつかの遺伝子の発現に影響を与えます」、Front。 Pharmacol。、vol。 7、2016年2月。[PubMed]
2. A. Kasian et al., “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats,” Behavioural Neurology, 2017. [Online]. Available: https://www.hindawi.com/journals/bn/2017/5091027/.
3. A. A. Zozulya et al。、「その抗不安分解活性の可能性のあるメカニズムとしてのエンケファリン分解酵素に対するSelankの阻害効果」、Bull。 exp。 Biol。 Med。、vol。 131、いいえ。 4、pp。315–317、2001年4月。[PubMed]
4. O. Y. Sokolov、V。K。Meshavkin、N。V。Kost、およびA. A. Zozulya、「感情的およびストレス反応の異なる表現型を持つマウスの血漿エンケファリン分解酵素の行動反応と活性に対するセランクの影響」、Bull。 exp。 Biol。医薬品。 [PubMed]
5. O. N. Uchakina et al。、「[不安 - 皮膚障害の患者におけるSelankの免疫調節効果]」、Zh。ネブロール。 psikhiatr。私は。 S. S. Korsakova、vol。 108、いいえ。 5、pp。71–75、2008。[PubMed]
6. A. A. Zozulia et al。、「[全身性不安障害と神経系の治療における新しいペプチド不安症セランクの有効性と可能なメカニズム]、Zh。ネブロール。 psikhiatr。私は。 S. S. Korsakova、vol。 108、いいえ。 4、pp。38–48、2008。[PubMed]
7. T. Kolomin、M。Shadrina、L。Andreva、P。Slominsky、S。Limborska、およびN. Myasoedov、「Tuftssin Analog Selankの下での炎症 - 炎症 - 炎症 - 炎症 - 炎症 - 炎症 - 炎症 - 炎症停止の発現」、Regul。 Pept。、vol。 170、いいえ。 1–3、pp。10-118–23、2011年10月。[PubMed]
8. T. I. Agapova et al。、「[ラット海馬および前頭皮質における脳由来の神経栄養因子と神経成長因子の遺伝子発現の一時的なダイナミクスに対するSEMAXの効果]、Mol。ジェネット。ミクロビオール。 virusol。、no。 3、pp。28–32、2008。[PubMed]
9. T. P. Semenova、I。I。Kozlovskiĭ、N。M。Zakharova、およびM. M. Kozlovskaia、「[Selankによる学習と記憶プロセスの実験的最適化]」、EKSP。クリン。 Farmakol。、vol。 73、いいえ。 8、pp。2–5、2010年8月。[PubMed]
10. S. I. AimnyはNiashです。 NLV。私たちは心です。彼はそうです。 Y .. Woving Up、Vuid。 63、知っています。 3、pp。 365–374、6月。 201
11. T. P. Semenova、M。M。Kozlovskaya、N。M。Zakharova、I。Kozlovskii、およびA. V. Zuikov、「初期オントゲン中に大脳カテコールアミン系に与えられた損傷後の認知プロセスに対するSelankの効果」、Bull。 exp。 Biol。 Med。、vol。 144、いいえ。 [PubMed]
12. N. V. Kost et al。、「[Semax and Selankは、ヒト血清からのエンケファリン分解酵素を阻害する]]、Bioorg。 Khim。、vol。 27、いいえ。 3、pp。180–183、2001年6月。Springer]

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. このウェブサイトで提供される製品は、ビトロ内の研究のためにのみ提供されています。 in-vitro研究（ラテン語：ガラス）は体の外側で行われます。これらの製品は薬や薬ではなく、病状、病気、病気を予防、治療、治療するためにFDAによって承認されていません。あらゆる種類の人間や動物への身体導入は、法律によって厳密に禁じられています。