PotencialBPC-157 e TB-500Synergy em WoundRepairA pesquisa revela que o BPC-157 e o TB-500, que ajudam a estimular diferentes vias bioquímicas de Healingvia, podem ter efeitos sinérgicos quando combinados.Migração celularA cicatrização bem -sucedida de feridas depende de fibroblastos, que regulam a produção da matriz extracelular, bem como as células do sistema imunológico. Para essas células realizarem seus empregos, eles precisam se mudar para a localização da lesão. Esse movimento, chamado de migração, depende fortemente da actina da proteína. Tanto o BPC-157 quanto o TB-500 são importantes na regulamentação da actina, o BPC-157 funciona no nível do gene para aumentar a produção de actina [1] .TB-500, uma proteína de actinbinding, ajuda a sequestrar a actina em áreas onde é mais útil para os filamentos de actina para permitir o movimento celular [2]. Juntos, o BPC-157 e o TB-500 trabalham com trabalho, para aumentar a quantidade e a função da actina e, assim, aumentar a taxa de fibroblastos e células do sistema imunológico migram para áreas de lesão.O big pictureinvolve crowthhormônioTB-500 e BPC-157 interagem com o hormônio do crescimento no processo de cicatrização. O BPC-157 aumenta a expressão dos receptores de hormônios do crescimento nos fibroblastos, aumentando a telagem dessas células e, portanto, sua capacidade de promover a regeneração dos tecidos moles [3]. WithTB-500 a bordo, os receptores hormonais de crescimento extras não serão desperdiçados porque os fibroblastos terão lojas adequadas de actina para fazer uso de sua vida útil alongada.Sobre o autorA literatura acima foi pesquisada, editada e organizada pelo Dr. E. Logan, M.D. Dr. ELOGAN é doutorado na Case Western Reserve University School of Medicine e um BS em biologia molecular.Autor de Jornada CientíficaAllan L. Goldstein, MD, Allan L. Goldstein is professor and Catharine B. & WiliamMcCormick Chair of the department of Biochemistry and Molecular Biology at TheGeorge Washington University School of Medicine and Health Sciences, where he hasserved since 1978. Thymosins were discovered in the mid 1960’s, when Allan Goldsteinfrom the Laboratory of Abraham White at the Albert Einstein College of Medicine in NewYork studied the role of the thymus in development of the vertebrate immune system. Heis a world-renowned authority on the thymus gland and the workings of the immunesystem, and co-discoverer of the thymosins. Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, andthe editor of several books in the fields of biochemistry, biomedicine, immunology andneuro-science. He is on the editorial boards of numerous scientific and medical journalsand has been a consultant to many re-search organizations in industry and government;,co-founder of The institute for Advanced Studies in Aging and Geriatric Medicine, a non-profit research and educational institute; a member of the Board of Trustees of the AlbertSabin Vaccine Institute, and serves as the Chairman of the Board of Regene Rx Biopharmaceuticals. Dr. Goldstein received his B.S. from Wagner College in 1959 and hisM.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of theAlbert Einstein College of Medicine from 1964 to 1972, and moved to the University ofTexas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.
Allan L. Goldstein, MD is being referenced as one of the leading scientists involved in theresearch and development of TB-500 and other Thymosins. In no way is thisdoctor/scientist endorsing or advocating the purchase, sale, or use of this product for anyreason. There is no affiliation or relationship, implied or otherwise, between PeptideSciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize.and credit the exhaustive research and development efforts conducted by the scientistsstudying this peptide. Dr. Goldstein is listed in [5]under the referenced citations.Recursos1.C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y-H. Hsu, and J.-H. S. Pang, “The promotingeffect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth,cell survival, and cell migration,”J.Appl. Physiol., vol. 110, no.3, pp.774-780, Oct[Physiology.org]
2.J. Kim and Y. Jung, “Potential Role of Thymosin Beta 4 in Liver Fibrosis,” Int. J.Mol. Sci., vol.16,no.5,pp.10624-10635,May 2015.[NCBI]
3.C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H.S.Pang,“Pentadecapeptide BPC157 enhances the growth hormone receptor expression in tendon fibroblasts,” Mol.Basel Switz.,vol.19,no.11,pp.19066-19077, NOV. 2014.[NCBI]
4.Song, Ran & Choi, Hyun & Yang, Hyung-In & Yoo, Myung & Park, Yong-Beom &Kim, Kyoung.(2012).Association between serum thymosin B4 levels of rheumatoidarthritis patients and disease activity and response to therapy. Clinicalrheumatology.31.1253-8.10.1007/s10067-012-2011-7.[Research Gate]
5.Philp, D., et al. “Thymosin β4 Promotes Angiogenesis, Wound Healing, and HairFollicle Development.”Mechanisms ofAgeing and Development, vol. 125, no. 2Feb.2004,pp.113-115,10.1016/i.mad.2003.11.005.[PubMed]
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