ProbeliveBPC-157 و TB-500Synergy في oundrepairتكشف الأبحاث أن BPC-157 و TB-500 ، اللذان يساعدان على تحفيز الجروح Healingvia مسارات كيميائية حيوية مختلفة ، قد يكون لها آثار تآزرية عند الجمع بينهما.هجرة الخلايايعتمد التئام الجروح الناجح على الخلايا الليفية ، التي تنظم إنتاج المصفوفة خارج الخلية ، وكذلك خلايا الجهاز المناعي. لكي تؤدي هذه الخلايا وظائفها ، فإنها لا تنقل إلى موقع الإصابة. هذه الحركة ، التي تسمى الهجرة ، تعتمد بشدة على الأكتين البروتين. كل من BPC-157 و TB-500 مهمان في تنظيم الأكتين BPC-157 يعمل على مستوى الجين لزيادة إنتاج الأكتين [1] .TB-500 ، وهو بروتين متكافئ ، يساعد على عزل الأكتين في المناطق التي يكون فيها أكثر فائدة لبناء الأفعال من الأكتين للسماح بالحركة الخلية [2]. معا ، يعمل BPC-157 و TB-500 من الناحية العملية لزيادة كمية ووظيفة الأكتين وبالتالي زيادة معدل الخلايا الليفية وخلايا الجهاز المناعي إلى مجالات الإصابة.The Big PictureInvolves Growthhormoneيتفاعل كل من TB-500 و BPC-157 مع هرمون النمو في عملية الشفاء. BPC-15777777777 تعبير مستقبلات هرمون النمو على الخلايا الليفية ، مما يعزز من ثلونجي هذه الخلايا وبالتالي قدرتها على تعزيز تجديد الأنسجة الرخوة [3]. WitTTB-500 على متن الطائرة ، لن تهدف مستقبلات هرمون النمو الإضافية لأن الأورام الخلوية سيكون لها متاجر كافية من الأكتين للاستفادة من عمرها الممدود.عن المؤلفتم البحث في الأدبيات المذكورة أعلاه وتحريرها وتنظيمها من قِبل الدكتور إي لوغان ، د. د. إلوجان ، حاصل على درجة الدكتوراه من كلية كيس ويسترن ريزيرف أوف ميديسين و في البيولوجيا الجزيئية.مؤلف المجلة العلميةAllan L. Goldstein, MD, Allan L. Goldstein is professor and Catharine B. & WiliamMcCormick Chair of the department of Biochemistry and Molecular Biology at TheGeorge Washington University School of Medicine and Health Sciences, where he hasserved since 1978. Thymosins were discovered in the mid 1960’s, when Allan Goldsteinfrom the Laboratory of Abraham White at the Albert Einstein College of Medicine in NewYork studied the role of the thymus in development of the vertebrate immune system. Heis a world-renowned authority on the thymus gland and the workings of the immunesystem, and co-discoverer of the thymosins. Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, andthe editor of several books in the fields of biochemistry, biomedicine, immunology andneuro-science. He is on the editorial boards of numerous scientific and medical journalsand has been a consultant to many re-search organizations in industry and government;,co-founder of The institute for Advanced Studies in Aging and Geriatric Medicine, a non-profit research and educational institute; a member of the Board of Trustees of the AlbertSabin Vaccine Institute, and serves as the Chairman of the Board of Regene Rx Biopharmaceuticals. Dr. Goldstein received his B.S. from Wagner College in 1959 and hisM.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of theAlbert Einstein College of Medicine from 1964 to 1972, and moved to the University ofTexas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry.
Allan L. Goldstein, MD is being referenced as one of the leading scientists involved in theresearch and development of TB-500 and other Thymosins. In no way is thisdoctor/scientist endorsing or advocating the purchase, sale, or use of this product for anyreason. There is no affiliation or relationship, implied or otherwise, between PeptideSciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize.and credit the exhaustive research and development efforts conducted by the scientistsstudying this peptide. Dr. Goldstein is listed in [5]under the referenced citations.موارد1.C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y-H. Hsu, and J.-H. S. Pang, “The promotingeffect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth,cell survival, and cell migration,”J.Appl. Physiol., vol. 110, no.3, pp.774-780, Oct[Physiology.org]
2.J. Kim and Y. Jung, “Potential Role of Thymosin Beta 4 in Liver Fibrosis,” Int. J.Mol. Sci., vol.16,no.5,pp.10624-10635,May 2015.[NCBI]
3.C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H.S.Pang,“Pentadecapeptide BPC157 enhances the growth hormone receptor expression in tendon fibroblasts,” Mol.Basel Switz.,vol.19,no.11,pp.19066-19077, NOV. 2014.[NCBI]
4.Song, Ran & Choi, Hyun & Yang, Hyung-In & Yoo, Myung & Park, Yong-Beom &Kim, Kyoung.(2012).Association between serum thymosin B4 levels of rheumatoidarthritis patients and disease activity and response to therapy. Clinicalrheumatology.31.1253-8.10.1007/s10067-012-2011-7.[Research Gate]
5.Philp, D., et al. “Thymosin β4 Promotes Angiogenesis, Wound Healing, and HairFollicle Development.”Mechanisms ofAgeing and Development, vol. 125, no. 2Feb.2004,pp.113-115,10.1016/i.mad.2003.11.005.[PubMed]
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