• hGH Fragment 176-191 peptide in cartilage regeneration
hGH Fragment 176-191 6mg
X
hGH Fragment 176-191 6mg

hGH Fragment 176-191 6mg

Kategorie:,

Kontakt w celu zamówienia
Napisz do nas teraz e-mail, aby złożyć zamówienie z pomocą indywidualną. Ograniczona sprzedaż! Akceptujemy Zelle, CashApp, Venmo, przelewy bankowe oraz kryptowaluty.

Wolna (1) 30 ml wody bakteriostatycznej
z rozkazami kwalifikowanymi po zakończeniu500 USD. (z wyłączeniem produktów kapsułkowych, peptydów kosmetycznych, kodów promocyjnych i wysyłki)

HGH Fragment 176-191is a small, synthetic piece of natural human growth hormone (hGH). It is often referred to as the “lipolytic fragment” for its ability to boost fat loss. It has been shown to help lowers blood sugar levels and promote cartilage healing without increasing long bone growth, increasing IGF-1 levels, or altering insulin sensitivity.
Wykorzystanie produktu:Ten produkt PRZEZNACZONY JEST WYŁĄCZNIE JAKO SUBSTANCJA CHEMICZNA BADAWCZA.To oznaczenie pozwala na stosowanie chemikaliów badawczych wyłącznie do testów in vitro i eksperymentów laboratoryjnych. Wszystkie informacje o produktach dostępne na tej stronie mają charakter wyłącznie edukacyjny. Wprowadzenie ciała jakiegokolwiek rodzaju do ludzi lub zwierząt jest surowo zabronione przez prawo. Tym produktem powinni zajmować się wyłącznie licencjonowani, wykwalifikowani profesjonaliści. Ten produkt nie jest lekiem, żywnością ani kosmetykiem i nie może być błędnie oznakowany, niewłaściwie używany ani błędnie określany jako lek, żywność czy kosmetyk.

What Is Fragment 176-191?

Fragment 176-191 (modified version ofAOD9604) is a small piece ofhuman growth hormone(hGH) that is sometimes referred to as the “lipolytic fragment.” Fragment 176-191 earned this latter name due to the fact that laboratory research has shown it to enhance fat burning, particularly in mice genetically engineered to produce large fat stores. Fragment 176-191 has been heavily researched in animal models because even while it preserves the fat-burning effects of hGH, it avoids some other effects of its parent protein such as increasing insulin-like growth factor-1 (IGF-1) levels, negatively impacting carbohydrate metabolism, altering insulin sensitivity, increasing long bone growth, and so forth. The targeted effects of fragment 176-191 make it useful for exploring human fat metabolism and may eventually provide the basis for developing anti-obesity medications.

Fragment 176-191 Peptide Structure

Źródło:PubChem Kolejność:Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-PheWzór molekularny:C78H125N23O23S2Masa cząsteczkowa:1817.12 g/molNumer CAS:66004-57-7

Fragment 176-191 Effects

1. Lowers Blood Sugar

Research in animals has revealed that the c-terminal end of hGH is primarily responsible for the protein’s hypoglycemic (lowering blood sugar) effects. Testing of at least six different fragments derived from this section of hGH has shown that fragment 176-191 is the most effective synthetic derivative of hGH for lowering blood sugar levels. This effect is secondary to a sustained increase in plasma insulin levels[1]. There is some interest in using fragment 176-191 as a treatment for both prediabetes and type 2 diabetes.

2. Fat Burning And Weight Loss

Fragment 176-191 has earned the nickname of “lipolytic fragment” because testing in mice has revealed the peptide to have substantial fat burning and weight loss properties. It is thought that this action is mediated through an increase in production of beta-3 adrenergic receptors (β3-AR or ADRB3)[2]. Agonist action at ADRB3 is known to directly increase fat burning in adipose tissue and is also responsible for thermogenesis in skeletal muscle[3]. Mice that have been genetically modified to produce no ADRB3 do not respond to the lipolytic effects of hGH or fragment 176-191[2]. Studies show that the increased fat burning associated with fragment 176-191 directly correlates with energy expenditure and thus weight reduction, leading to a nearly 50% reduction in weight gain in obese animals over a three-week course[4]. Interestingly, the weight loss effects were seen only in obese mice, with lean mice maintaining normal body weight, on average, even when exposed to fragment 176-191[2]. These findings indicate that there are secondary regulatory pathways for lipolysis that override ADRB3 function when body weight is at or near ideal, opening up areas for additional research into energy homeostasis.Body weight in genetically obese mice after two weeks of treatment with a single daily dose of fragment 176-191 Source:Oxford Academic
Effect of saline (control), fragment 176-191, and hGH on white adipose tissue mass in obese mice over 14 days Source:Oxford Academic

3. Promotes Cartilage Regeneration

Though fragment 176-191 is primarily of interest for its lipolytic properties, the peptide is under investigation for other possible benefits. Of note, a 2015 article out of Korea revealed that fragment 176-191 may be able to potentiate the effects of hyaluronic acid injections in promoting cartilage regeneration. Studies in rabbits indicated that weekly injections of fragment 176-191 increase laboratory measures of cartilage growth and that co-administration of the peptide with hyaluronic acid (HA) produces even more substantial effects. Similarly, the study found that fragment 176-191, both alone and in combination with HA, reduces disability associated with osteoarthritis. There is hope that this may lead to advanced therapies for osteoarthritis and may even eliminate the need for surgery in certain settings[7].

Fragment 176-191 Safety Studies

There is some concern that the use of hGH or its derivatives for weight control may have unwanted side effects. This concern arises from the fact that studies of hGH have shown that long-term exogenous administration, while increasing lean body mass and decreasing adipose tissue, can also cause:
    increased insulin resistance, diabetes, acromegaly, cancer, hypertension (high blood pressure), and edema (swelling).
In 2013, a study published in the Journal of Endocrinology and Metabolism evaluated six studies of fragment 176-191 to assess the rate and significance of negative effects associated with the peptide. The study, included only research that followed the randomized, double-blinded, placebo-controlled model of a phase IIb clinical trial in order to keep the highest possible standards of evidence. It found that IV and oral administration of Fragment 176-191, when compared to placebo, led to no changes in:
    physical findings, laboratory parameters, glucose levels, glucose tolerance, insulin sensitivity, IGF-1 levels, or rates of adverse events (e.g. headache)[4], [5].
The results of this meta-analysis suggest that fragment 176-191 offers many of the benefits of hGH without the associated negative (and often serious) side effects. These findings further the argument for pursuing regulatory approval for use of fragment 176-191 in the clinical setting, but also offer insight into the regulation of human growth, fat deposition, and energy homeostasis. These findings make it clear that it is possible to target fat loss without affecting energy homeostasis in other nutrient pathways, opening the door for a deeper exploration of human energy regulation and methods of manipulating it. It is worth noting that while hGH has anabolic effects on muscle, fragment 176-191 was specifically selected for its ability to avoid anabolism entirely. This is critical to ensuring that the peptide has targeted lipolytic effects and does not produce acromegaly or any of the other conditions associated with hGH administration. Studies in mice reveal that fragment 176-191 does not increase cell proliferation[6].

Fragment 176-191 Future Research

The primary area of research for fragment 176-191 is in weight loss and lipolysis where significant effort is being expended to learn how the peptide can be used to understand fat metabolism and energy homeostasis. The most active secondary area of research is in connective tissue regeneration, particularly cartilage repair.

Autor artykułu

Powyższa literatura została zbadana, zredagowana i zorganizowana przez dr Logana, M.D. Dr Logan posiada tytuł doktoraWydział Medyczny Case Western Reserve Universityoraz licencjat z biologii molekularnej.

Scientific Journal Article

Frank NG, M.D.is one of the leading scientists discovering how both AOD9604 and Fragment 176-191 function. He extensively studied their effects on lipid metabolism in obese mice, fat oxidation, weight loss, oral digestion, glucose transport, and hyperglycemia. He has over 64 publications and studies at the Department of Biochemistry and Molecular Biology — Monash University, Australia. Frank NG, M.D. is being referenced as one of the leading scientists involved in the research and development of Fragment 176-191. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between
Guru peptydówand this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Frank NG, M.D. is listed in [1] [2] and [4] under the referenced citations.

Cytowania

    F. M. Ng and J. Bornstein, “Hyperglycemic action of synthetic C-terminal fragments of human growth hormone,” Am. J. Physiol., vol. 234, no. 5, pp. E521-526, May 1978. M. Heffernan et al., “The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice,” Endocrinology, vol. 142, no. 12, pp. 5182–5189, Dec. 2001. R. Ferrer-Lorente, C. Cabot, J.-A. Fernández-López, and M. Alemany, “Combined effects of oleoyl-estrone and a beta3-adrenergic agonist (CL316,243) on lipid stores of diet-induced overweight male Wistar rats,” Life Sci., vol. 77, no. 16, pp. 2051–2058, Sep. 2005. F. M. Ng, J. Sun, L. Sharma, R. Libinaka, W. J. Jiang, and R. Gianello, “Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone,” Horm. Res., vol. 53, no. 6, pp. 274–278, 2000. H. Stier, E. Vos, and D. Kenley, “Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans,” J. Endocrinol. Metab., vol. 3, no. 1–2, pp. 7-15–15, Apr. 2013. M. A. Heffernan et al., “Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment,” Int. J. Obes. Relat. Metab. Disord. J. Int. Assoc. Study Obes., vol. 25, no. 10, pp. 1442–1449, Oct. 2001. D. R. Kwon and G. Y. Park, “Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model,” Ann. Clin. Lab. Sci., vol. 45, no. 4, pp. 426–432, Jul. 2015.
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.Produkty oferowane na tej stronie są przeznaczone wyłącznie do badań in vitro. Badania in vitro (łac. w szkle) przeprowadza się poza ciałem. Te produkty nie są lekami ani lekami i nie zostały zatwierdzone przez FDA do zapobiegania, leczenia lub leczenia jakichkolwiek schorzeń, dolegliwości czy chorób. Wprowadzenie ciała jakiegokolwiek rodzaju do ludzi lub zwierząt jest surowo zabronione przez prawo.
 

Zapytanie o żądanie

O nas

PeptideGurus jest wiodącym dostawcą amerykańskich peptydów badawczych, oferującym produkty najwyższej jakości w konkurencyjnych cenach. Stawiając na doskonałą jakość i obsługę klienta, zapewniają bezpieczny i wygodny proces zamawiania z globalną wysyłką.

Produkty

Poproś o wycenę

  • Guru peptydów
    • info@peptidegurus.com
  • Glendale, AZ, USA

    • KONTAKT

    Zapytanie o żądanie